The field of nurse anesthesia has evolved from a low status, women’s specialty to a high status profession where males comprise nearly half of all employees. This study explores reasons for men’s influx into nurse anesthesia and the impact they have had on the profession. Twenty semi-structured interviews with certified registered nurse anaesthetists (CRNAs) and key informants were conducted. In addition, data on CRNAs from the US National Sample Survey of Registered Nurses and historical archives were analyzed. The interviews suggest that men are increasingly present within nurse anesthesia because of its autonomous, lucrative, and technical nature. Male CRNAs spend significantly more time in administration, and earn more on average, than women. Female CRNAs work fewer hours compared to males, which is likely a reflection of their family responsibilities. Reasons for entry into the occupation evolve over time given the lengthy process of invasion.