Significant salary differences between male and female PAs have been noted. Several variables–hours worked per week, weeks worked per year, number of patients seen per week, and average fee per patient–were examined to assess their contribution to the differences in salary for PAs practicing in family medicine, internal medicine, and pediatrics. Although female PAs were found to earn significantly less than their male colleagues, the discrepancy could largely be explained when salary was examined as a proportion of revenue generated for the practice. The survey findings are compared with research findings on male and female physicians’ salaries.