Purpose: To present a framework for nurse practitioners (NPs) who wish to engage in outcomes research.

Data source: Review of scientific literature on the design of outcomes research.

Conclusion: The structure and process of outcomes research includes both the research protocol and the decisions related to designing and implementing a study. Each identified step of the presented framework incorporates issues related to decision making relevant for that specific component of the research protocol.

Implications for practice: Practical advice guides the NP in beginning to identify researchable problems within the clinical setting suited to outcomes research. Using a framework to design an outcomes study assists the NP in making key study decisions.